Estrogen linked to heart diseases

Body: 

Nov 14, 2014
Western University study links estrogen to heart disease

London Community News
Researchers at Western University are getting to the bottom of why some women are more susceptible to heart disease than others.

They’ve found that an estrogen receptor, previously shown to regulate blood pressure in women, also plays an important role in regulating low-density lipoprotein (LDL) cholesterol levels. LDL, also known as bad cholesterol, drives the process that leads to heart disease.

In a release, the university said the “finding provides evidence that the hormone estrogen plays a key role in regulating two of the most common risk factors for heart disease and stroke. It may also help to explain why post-menopausal women with lower levels of estrogen are more likely to have multiple risk factors for heart disease.

Dr. Ross Feldman, a clinical pharmacologist at London Health Sciences Centre and a scientist at the Schulich School of Medicine & Dentistry’s Robarts Research Institute, and his colleagues showed that the G-protein coupled estrogen receptor 30 (GPER) when activated by estrogen helps lower LDL cholesterol levels in the blood by inhibiting the protein PCSK-9.

Their findings were published Nov. 13 in the journal Arteriosclerosis, Thrombosis and Vascular Biology.

“This is a really important finding because there has always been some indication that estrogen was protective in lowering cholesterol, but we didn’t understand how,” Feldman said in the release. “The mechanism of estrogen’s effect was kind of a black box because we didn’t know the receptors responsible for doing it.”

http://www.londoncommunitynews.com/news-story/5029293-western-university...
http://www.scienceclarified.com/He-In/Immune-System.html
http://blackburnnews.com/london/london-news/2014/11/13/uwo-identifies-es...

I can see that this is a real article, though your second link is not relevant to the topic, so I have to wonder if we are being spammed. We typically do not tolerate new "members" posting links here.

That being said.....it's important for post-menopausal women to learn to regulate their hormone levels naturally. It's well known that women are much more at risk of heart disease after hysterectomy. Hormone replacement is quite another matter, and this article might possibly lead women to believe that they should be taking estrogen. That would be an irresponsible message to send.

I'll leave it to the forum cops to decide if this user is for real. I don't think he or she came here to discuss prolapse. - Surviving

http://circ.ahajournals.org/content/93/10/1928.full

I found this article and it said the evidence was not conclusive. It also said that there is a increased risk of breast cancer and vaginal bleeding with these therapies. My own mother's tryglicerides sky rocked from using Premarin. Do your own studying ladies, before falling for anything that seems too good to be true.
The jury is still out for me on this.

I do want to point out that the article doesn't specifically appear to be pushing estrogen therapy. But it does indicate that lower estrogen levels after menopause could be related to more heart disease. I just wanted to point out that women could read the study and conclude that they should be taking estrogen after menopause. I think this is a dangerous message. - Surviving

Hi Surviving,

I have occasionally used Premarin cream intra-vaginally. It did help my symptoms. I used it sparingly and now no longer need it. I think the connection between Estrogen and cholesterol levels is not 100% conclusive and doesn't take into consideration the various pre-existing conditions some women may already have, which HAVE definitely been proven to contribute to heart disease, such as Diabetes and high blood pressure just to name a few.